Comparison Between the Effect of Lincomycin and Azithromycin on Streptococcal Pharyngitis
DOI:
https://doi.org/10.59675/M225Keywords:
Acute pharyngitis, azithromycin, lincomycin, group A streptococcus tonsillitis.Abstract
Acute follicular tonsillitis is a common disorder that affects mainly pediatric and teenage age groups. Although it is highly curable, there are still many complications (like rheumatoid arthritis, valvular heart disease, middle ear infection, meningeal infection, and sinusitis) that make this infection in group A streptococci (G.A.S.) require proper and fast treatment. Azithromycin macrolide antibiotics have been used for a long time as a substitute for lincomycin antibiotics, whereas penicillins were shown to be allergic for some patients.
Aim of the study: to assess the potency of either azithromycin or lincomycin on G.A.S. pharyngitis
Patients and method: 84 patients with acute pharyngeal infection with G.A.S. were enrolled in this study and divided randomly into two equal groups. Group A received azithromycin, and group B received lincomycin. Both groups received their treatment for 5 days, after which rapid strep test (RST), leucocyte count WBC, and C-reactive protein (CRP) were done and compared to the 1st day of identification. Statistical analysis was done to evaluate the statistical significance of tested drugs. Results: Overall, the results demonstrate that lincomycin has a higher rate of curing G.A.S. tonsillitis than azithromycin, making it a preferred antibiotic agent.
References
Ughasoro, M.D., et al., The profile of microorganisms that associate with acute tonsillitis in children and their antibiotics sensitivity pattern in Nigeria. Scientific reports, 2021. 11(1): p. 20084. DOI: https://doi.org/10.1038/s41598-021-99570-9
Büttner, R., et al., Expert consensus-based clinical recommendation for an integrative anthroposophic treatment approach to acute tonsillitis in childhood. Complementary Therapies in Medicine, 2024. 81: p. 103031. DOI: https://doi.org/10.1016/j.ctim.2024.103031
Ece, B. and S. Aydin, Can shear wave elastography help differentiate acute tonsillitis from normal tonsils in pediatric patients: A prospective preliminary study. Children, 2023. 10(4): p. 704. DOI: https://doi.org/10.3390/children10040704
Pardeshi, P. and V.V. Patil, A review: on homoeopathic management in acute and recurrent tonsillitis in paediatric age group of 2 to 15 yrs. Sustainability, Agri, Food and Environmental Research-DISCONTINUED, 2023. 12. DOI: https://doi.org/10.7770/safer-V13N2-art727
Al-Tameemi, K., R. Hraishawi, and F.L. Aaiz, Isolation, identification and evaluation of resistance of bacterial isolates from patients with tonsillitis. Ann Trop Med Public Health, 2020. 23: p. 10. DOI: https://doi.org/10.36295/ASRO.2020.231017
Huang, P., et al., A five-dimensional network meta-analysis of Chinese herbal injections for treating acute tonsillitis combined with western medicine. Frontiers in Pharmacology, 2022. 13: p. 888073. DOI: https://doi.org/10.3389/fphar.2022.888073
Sherkatolabbasieh, H., et al., Antibiotic susceptibility evaluation of bacterial agents causing infection in children with acute tonsillopharyngitis. Infectious Disorders-Drug Targets (Formerly Current Drug Targets-Infectious Disorders), 2021. 21(6): p. 67-71. DOI: https://doi.org/10.2174/1871526520666201116102441
Lima, L., et al., Efficacy of azithromycin versus other antibiotics in the treatment of patients with upper respiratory tract infections. Clin Microbiol Infect, 2021. 6: p. 1-4. DOI: https://doi.org/10.15761/CMID.1000183
McGuire, E., et al., Time to negative throat culture following initiation of antibiotics for pharyngeal group A Streptococcus: a systematic review and meta-analysis up to October 2021 to inform public health control measures. Eurosurveillance, 2023. 28(15): p. 2200573. DOI: https://doi.org/10.2807/1560-7917.ES.2023.28.15.2200573
Pikul, K.V., et al., Diphtheria: current public health challenge in Ukraine and worldwide (literature review). 2021. DOI: https://doi.org/10.36740/WLek202101127
Achmad, H., et al., The Impact of Using Antibiotic Drugs in Pediatric Dentistry. International Journal of Pharmaceutical Research (09752366), 2020. 12(4). DOI: https://doi.org/10.31838/ijpr/2020.12.04.400
Ingelbeen, B., et al., Antibiotic use prior to seeking medical care in patients with persistent fever: a cross-sectional study in four low-and middle-income countries. Clinical Microbiology and Infection, 2021. 27(9): p. 1293-1300. DOI: https://doi.org/10.1016/j.cmi.2020.11.003
Singhal, M., et al., Macrolide antibiotics, in Antibiotics-Therapeutic Spectrum and Limitations. 2023, Elsevier. p. 167-181. DOI: https://doi.org/10.1016/B978-0-323-95388-7.00027-9
Organization, W.H., WHO laboratory manual for the diagnosis of diphtheria and other related infections. 2021.
El-Desoukey, R., Bacterial Resistance to Antibiotic in Human and Animals. EC Veterinary Science, 2022. 7: p. 51-62.
Coutinho, G., et al., Worldwide comparison of treatment guidelines for sore throat. International Journal of Clinical Practice, 2021. 75(5): p. e13879. DOI: https://doi.org/10.1111/ijcp.13879
Downloads
Published
Issue
Section
License
Copyright (c) 2024 Academic International Journal of Medical Update
This work is licensed under a Creative Commons Attribution 4.0 International License.
