The Impact and Organization of Human Histidine Rich Calcium Binding Protein (HRC) in Patients with Supraventricular Tachycardia
DOI:
https://doi.org/10.59675/M327Keywords:
Supraventricular Tachycardia, Human Histidine Rich Calcium Binding Protein, Electrolytes, Biomarkers, Calcium Homeostasis.Abstract
Supraventricular tachycardia (SVT) is one of the serious heart rhythms that demand proper identification of biomarkers in the early diagnosis and risk stratification. Electrophysiological tests and serum biomarkers are standardized cardiology devices that are necessary in identifying patients who risk developing SVT and other cardiac disorders. The aim of the given study was to test the role of human histidine-rich calcium-binding protein (HRC) among patients with supraventricular tachycardia and determine whether this protein can be used as a diagnostic biomarker. This research involved 128 individuals in two groups namely those who appeared healthy and those diagnosed with SVT (64). The age of the participants varied between 17-68 years, with the body mass index between 30.4 and 49.9kg/m 2. The subjects used were 61 females and 67 males. The study was carried out in the period between March and September 2021. The enzyme-linked immunosorbent assay (ELISA) was used to measure serum HRC levels. The values showed that SVT patients exhibited very poor serum HRC levels relative to healthy controls (5.49 + 2.65 pg/mL vs 9.40 + 3.88 pg/mL, P ≤ 0.05). There were also no major differences by age. Such observations indicate that dysregulation of HRC can be a possible cause of arrhythmogenesis due to calcium homeostasis changes and can also be a biomarker of SVT diagnosis.
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