The Activity of Nourseothricin Against Drug-Resistant Bacteria

Authors

  • Lames H. ALManseeqanaa Department of Basic Medical Sciences, College of Dentistry, University of Kerbala, Iraq Author
  • Mohammed Razzak Ali Department of Microbiology, College of Medicine, Al-Nahrain University, Iraq Author
  • Raed H. Ogaili Department of Basic Medical Sciences, College of Dentistry, University of Kerbala, Iraq Author

DOI:

https://doi.org/10.59675/

Keywords:

Adiponectin, Gestational diabetes, Impaired glucose tolerance, Glucose tolerance test

Abstract

Because nurseothricin successfully kills MDR bacteria, it may be useful in treating illnesses that are difficult to treat with traditional therapy. In contrast to highly resistant single-target antibiotics, nourseothricin, a broad-spectrum antibiotic, inhibits bacterial protein synthesis. The article also covers how nourseothricin works in conjunction with other antibiotics to destroy bacteria and minimize resistance. Antibiotic misuse has become a worldwide issue. Nursothricin, due to its unique mechanism and efficacy against drug-resistant bacteria, is an exciting potential treatment for a variety of disorders.

The paper discusses the gaps in our current understanding of nourseothricin as well as the necessity for additional research into its medical potential. Resistance to nursothricin, like resistance to other antimicrobials, is a severe problem. Extensive precautionary research is required to ensure user safety and reduce the danger of injury. More research is needed to determine whether nourseothricin works against antibiotic-resistant microorganisms. Pharmacokinetic studies and clinical trials are required to investigate its therapeutic efficacy and long-term effects. The safe and effective dosage of nourseothricin is determined through such study.

Nourseothricin offers new hope for the treatment of antibiotic-resistant bacterial infections. Because of its unique mechanism and synergistic effects, it can be used to combat antibiotic resistance. More research is required to maximize its potential while minimizing any potential drawbacks. Nurseothricin has the potential to improve global health if its limitations, safety, and clinical significance are addressed. Antibiotic resistance can only be avoided by creating new antimicrobials such as nourseothricin.

References

Cui X, Lü Y, Yue C. Development and research progress of anti-drug resistant bacteria drugs. Infection and drug resistance. 2021:5575-93.

Cundliffe E, Demain AL. Avoidance of suicide in antibiotic-producing microbes. Journal of Industrial Microbiology and Biotechnology. 2010;37(7):643-72.

Cole ST. Who will develop new antibacterial agents? Philosophical Transactions of the Royal Society B: Biological Sciences. 2014;369(1645):20130430.

Le Roes-Hill M, Durrell KA, Kügler JH. Biosurfactants from Actinobacteria: State of the Art and Future Perspectives. Microibial Biosurfactants and their Environmnetal and Industrial Applications. 2019:174-208.

Ventola CL. The antibiotic resistance crisis: part 1: causes and threats. Pharmacy and therapeutics. 2015;40(4):277.

Ali T, Ali I, Khan NA, Han B, Gao J. The growing genetic and functional diversity of extended spectrum beta-lactamases. BioMed research international. 2018;2018.

Read AF, Woods RJ. Antibiotic resistance management. Evolution, medicine, and public health. 2014;2014(1):147.

Nikaido H, Pagès J-M. Broad-specificity efflux pumps and their role in multidrug resistance of Gram-negative bacteria. FEMS microbiology reviews. 2012;36(2):340-63.

Sheu C-C, Chang Y-T, Lin S-Y, Chen Y-H, Hsueh P-R. Infections caused by carbapenem-resistant Enterobacteriaceae: an update on therapeutic options. Frontiers in microbiology. 2019;10:80.

Smith KP, Kang Y-S, Green AB, Dowgiallo MG, Miller BC, Chiaraviglio L, et al. Profiling the in vitro and in vivo activity of streptothricin-F against carbapenem-resistant Enterobacterales: A historic scaffold with a novel mechanism of action. bioRxiv. 2021:2021-06.

Vercelli C, Gambino G, Amadori M, Re G. Implications of Veterinary Medicine in the comprehension and stewardship of antimicrobial resistance phenomenon. From the origin till nowadays. Veterinary and Animal Science. 2022;16:100249.

Ingber DE. Is it time for reviewer 3 to request human organ chip experiments instead of animal validation studies? Advanced Science. 2020;7(22):2002030.

Gianetti B. Candida albicans Phenotypic Switching and Functional Plasticity in the Mammalian Host: University of California, San Francisco; 2017.

Ogawara H. Comparison of antibiotic resistance mechanisms in antibiotic-producing and pathogenic bacteria. Molecules. 2019;24(19):3430.

Yin D, Guo Y, Li M, Wu W, Tang J, Liu Y, et al. Performance of VITEK 2, E-test, Kirby–Bauer disk diffusion, and modified Kirby–Bauer disk diffusion compared to reference broth microdilution for testing tigecycline susceptibility of carbapenem-resistant K. pneumoniae and A. baumannii in a multicenter study in China. European Journal of Clinical Microbiology & Infectious Diseases. 2021;40:1149-54.

Brown HE, Telzrow CL, Saelens JW, Fernandes L, Alspaugh JA. Sterol-response pathways mediate alkaline survival in diverse fungi. MBio. 2020;11(3):10-1128.

Shih P-Y, Liao Y-T, Tseng Y-K, Deng F-S, Lin C-H. A potential antifungal effect of chitosan against Candida albicans is mediated via the inhibition of SAGA complex component expression and the subsequent alteration of cell surface integrity. Frontiers in Microbiology. 2019;10:602.

18. Sampson LDP. High throughput drug discovery in S. cerevisiae: The characterisation of FC-592 and FC-888. 2012.

Li B, Webster TJ. Bacteria antibiotic resistance: New challenges and opportunities for implant‐associated orthopedic infections. Journal of Orthopaedic Research®. 2018;36(1):22-32.

Tagliaferri TL, Jansen M, Horz H-P. Fighting pathogenic bacteria on two fronts: phages and antibiotics as combined strategy. Frontiers in cellular and infection microbiology. 2019;9:22.

Ksiezopolska E, Schikora-Tamarit MÀ, Beyer R, Nunez-Rodriguez JC, Schüller C, Gabaldón T. Narrow mutational signatures drive acquisition of multidrug resistance in the fungal pathogen Candida glabrata. Current Biology. 2021;31(23):5314-26.

Lees P, Pelligand L, Giraud E, Toutain PL. A history of antimicrobial drugs in animals: Evolution and revolution. Journal of Veterinary Pharmacology and Therapeutics. 2021;44(2):137-71.

Gupta SK, Shukla P. Gene editing for cell engineering: trends and applications. Critical reviews in biotechnology. 2017;37(5):672-84.

Choudhary MI, Römling U, Nadeem F, Bilal HM, Zafar M, Jahan H, et al. Innovative Strategies to Overcome Antimicrobial Resistance and Tolerance. Microorganisms. 2022;11(1):16.

Epp E, Vanier G, Harcus D, Lee AY, Jansen G, Hallett M, et al. Reverse genetics in Candida albicans predicts ARF cycling is essential for drug resistance and virulence. PLoS pathogens. 2010;6(2):e1000753.

Ruddaraju LK, Pammi SVN, sankar Guntuku G, Padavala VS, Kolapalli VRM. A review on anti-bacterials to combat resistance: From ancient era of plants and metals to present and future perspectives of green nano technological combinations. Asian Journal of Pharmaceutical Sciences. 2020;15(1):42-59.

Gao Y, Skowyra ML, Feng P, Rapoport TA. Protein import into peroxisomes occurs through a nuclear pore–like phase. Science. 2022;378(6625):eadf3971.

Kliegman JIM. Chemical-Genetic Characterization of TORC2 in Yeast: University of California, San Francisco; 2013.

Manaia CM, Vaz-Moreira I, Nunes OC. Antibiotic resistance in waste water and surface water and human health implications. Emerging organic contaminants and human health. 2012:173-212.

Ma F, Xu S, Tang Z, Li Z, Zhang L. Use of antimicrobials in food animals and impact of transmission of antimicrobial resistance on humans. Biosafety and Health. 2021;3(1):32-8.

Yao T, Asayama Y. Animal‐cell culture media: History, characteristics, and current issues. Reproductive medicine and biology. 2017;16(2):99-117.

Harding J, Roberts RM, Mirochnitchenko O. Large animal models for stem cell therapy. Stem cell research & therapy. 2013;4(2):1-9.

Vanherp L. Multimodal imaging of infection: a platform for in vivo assessment of cryptococcosis in mouse models. 2020.

Wyllie S, Patterson S, Stojanovski L, Simeons FRC, Norval S, Kime R, et al. The anti-trypanosome drug fexinidazole shows potential for treating visceral leishmaniasis. Science translational medicine. 2012;4(119):119re1-re1.

Ramos-Vega A, Angulo C, Bañuelos-Hernández B, Monreal-Escalante E. Microalgae-made vaccines against infectious diseases. Algal Research. 2021;58:102408.

Sulis G, Sayood S, Gandra S. Antimicrobial resistance in low-and middle-income countries: current status and future directions. Expert review of anti-infective therapy. 2022;20(2):147-60.

Hunter PA, Dawson S, French GL, Goossens H, Hawkey PM, Kuijper EJ, et al. Antimicrobial-resistant pathogens in animals and man: prescribing, practices and policies. Oxford University Press; 2010.

Published

26-05-2024

Issue

Section

Articles

How to Cite

Lames H. ALManseeqanaa, Mohammed Razzak Ali, & Raed H. Ogaili. (2024). The Activity of Nourseothricin Against Drug-Resistant Bacteria. Academic International Journal of Medical Sciences , 1(2), 18-27. https://doi.org/10.59675/